僅用于工業(yè)應(yīng)用或科學(xué)研究，不可用于人類或動物的臨床診斷或治療，非藥用.SB-431542 is a TGF-β receptor kinase inhibitor （TRKI）. SB-431542 has inhibitory activity for ALK4, ALK5 and ALK7 with IC50 values of 1 μM, 0.75 μM and 2 μM, respectively. SB-431542 also inhibits TGF-β-induced transcription, gene expression, apoptosis, and growth suppression. SB-431542 can be used for the research of cancer and signal transduction pathways.SB-431542 是 TGF-β 受體激酶抑制劑 （TRKI）。SB-431542 對 ALK4、ALK5 和 ALK7 活性有抑制作用， IC50 值分別為 1 μM、0.75 μM 和 2 μM。SB-431542 還能抑制 TGF-β 誘導(dǎo)的轉(zhuǎn)錄、基因表達、細胞凋亡和生長抑制。SB-431542 可用于癌癥及其信號轉(zhuǎn)導(dǎo)途徑的研究